Trap-Free 2D LC/MS System For Quadrupole LCMS

Trap-Free 2D LC/MS System For Quadrupole LCMS

Question:
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?

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Application Specific LC-MS Systems

Shimadzu Corp.

Application Specific LC-MS Systems

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Metabolites Method Package Suite

Shimadzu Corp.

This suite allows comprehensive analysis of over 1900 metabolites without the need for investigation of separation conditions, MRM optimization or parameter settings. The range of metabolites spans both hydrophilic and hydrophobic compounds, including amino acids, short-chain fatty acids, sugars, nucleotides, bile acids, and lipids. The suite consists of five LC/MS/MS Method Packages including ready-to-use methods for the LCMS-8050/8060 series, the LC/MS/MS MRM Library for Phospholipid Profiling, the Smart Metabolites Database™ for GC/MS(GC/MS/MS), and a Multi-omics Analysis Package. The Multi-omics Analysis Package included in this product supports not only regular analysis but also large volume data analysis and interpretation. The Multi-omics Analysis Package includes metabolic pathways and other contour maps corresponding to the Method Packages. This makes it easy to visualize fluctuations in the quantitative values of metabolites across metabolic pathways. Data filtering functions and statistical analysis can be applied to the network of compound relationships, providing a total solution for metabolite analysis.

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LC/MS/MS Method Package For Aminoglycoside Antibiotics

Shimadzu Corp.

*Complete method for fast quantitative screening of 13 aminoglycosides in meat, eggs and milk.*Increase identification confidence with MRM Spectrum mode and LabSolutions Insight™ Screening.*No ion-pairing reagent required.*Includes single sample preparation protocol usable for meat, eggs and milk.

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LC/MS/MS Method Package For Short Chain Fatty Acids

Shimadzu Corp.

Of the short-chain fatty acids produced by intestinal bacteria, acetic acid, propionic acid, and butyric acid are well known, and it has been reported that there are some connections between them and lifestyle-related diseases such as obesity and diabetes. Generally speaking, short-chain fatty acids are highly volatile and highly hydrophilic. This makes it dificult to perform LCMS analysis using a conventional reverse phase system. For that reason, this method package targets short-chain fatty acids (C2 to C5) that have been derivatized using 3-nitrophenylhydrazine (3-NPH). Through making settings for MRM transitions, it can be used for the simultaneous analysis (of 22 components), including organic acids related to the central metabolic pathways.

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LC/MS/MS Method Package For Mycotoxins

Shimadzu Corp.

Mycotoxins are highly toxic chemical byproducts from fungi commonly found in crops, and residual content in foods are regulated the world over. This method package provides simultaneous multi-component analysis conditions for mycotoxins subject to the regulations in Japan, the USA, the EU, and China.

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LC/MS/MS Method Package For Bile Acids

Shimadzu Corp.

Bile acids are primarily produced through the breakdown of cholesterol in the liver. Primary bile acids can then be conjugated with taurine or glycine and/or converted into secondary bile acids by gut bacteria. Their role as digestive surfactants to promote the absorption of lipids is well-known, but they also act as hormones in the regulation of various metabolic pathways.

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LC/MS/MS Method Package For Restricted Chemicals In Textiles

Shimadzu Corp.

In recent years, while many issues have been raised related to food safety and the environment, the safety of textiles, which are indispensable for everyday life, has become a particular concern. Countries throughout the world, and especially in the EU, are regulating and investigating hazardous chemicals in textiles. Additionally, regulations have been tightened with respect to hazardous chemicals in textiles. This includes the adoption of the OEKO-TEX® Standard 100, a globally consolidated, independent examination and authentication system for textiles, and the implementation of voluntary regulations by various manufacturers. In addition to the currently regulated components, this method package provides analysis methods covering the major compounds in the OEKO-TEX® Standard 100 and voluntary regulations by various manufacturers.

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LC/MS/MS Method Package For D/L Amino Acids

Shimadzu Corp.

Most important amino acids exist as stereoisomers. D- and L- forms of mirror image isomers, or enantiomers, are named according to their activity on polarized light. By using CROWNPAK CR-I(+) and CR-I(-) columns with chiral stationary phases, the D- and L-forms of amino acids can be analyzed separately. With CR-I(+) elution order is from D- to L-, and with CR-I(-) the elution order is reversed.

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Exact Mass Database For Endogenous Metabolites

Shimadzu Corp.

The physical properties of target compounds in metabolomics can vary greatly. An analysis method tailored to the target compounds is therefore needed for comprehensive measurements of metabolites.This database contains multiple ready-to-use methods for comprehensive analysis of metabolites with different properties. Pretreatment examples are also included for various metabolites and samples. The user can begin a metabolomics analysis without time-consuming evaluation of LC or MS conditions.

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LC/MS/MS Rapid Toxicology Screening System

Ver.3 - Shimadzu Corp.

This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization. Rapid simultaneous analysis methods with analysis times under 15 mins are included for 235 compounds including drugs of abuse, psychoneurotic drugs and sedatives. The system also provides optimised conditions for synchronised survey scans used in screening measurements (conditions adopted for the product ion spectrum as a threshold value for the intensity in MRM).

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LC/MS/MS Forensic Toxicology Database

Shimadzu Corp.

The database includes information on drugs of abuse, hypnotics, psychotropics, pesticides, prescription drugs and natural toxins.

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DPiMS™-8060 Method Package For Rapid Toxicology Screening Ver.2

Shimadzu Corp.

With the DPiMS-8060, time-consuming pretreatment steps associated with forensic samples are almost completely eliminated. Begin analysis after only simple dilution and centrifugation steps. The DPiMS-8060 is therefore extremely well-suited for mass analysis via rapid screening.

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LC/MS/MS Method Package For Residual Pesticide Ver. 3

Shimadzu Corp.

■　Database compatible with LabSolutions Connect, a tool that automates MRM tuning and optimization

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LC/MS/MS Method Package For Water Quality Analysis

Shimadzu Corp.

Shimadzu provides method files, including pre-registered MRM parameters with optimized quantitative and reference ions, LC separation parameters, and retention times and peak identification parameters for each compound, as well as report templates for outputting quantitation results, as a package. If retention times are adjusted when the system is introduced, based on the HPLC configuration delivered, the analysis process can be started as soon as the specified columns, mobile phases, and standard samples are supplied.

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LC/MS/MS Method Package For Veterinary Drugs Ver. 2

Shimadzu Corp.

*Method package including 129 veterinary drug compounds, more than 3 times as many as Ver. 1*High-speed method with just 16.5 mins detection time*Pretreatment program to improve the peak shape for polar veterinary drug compounds*Data analysis is made simple with LabSolutions Insight™

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ASAPrep

Shimadzu Corp.

Compound isolation, purity analysis, and impurity analysis in pharmaceutical drug development presents increasing challenges to the industry as there is a clear need to enhance productivity and ensure compliance with evolving regulatory requirements. Such challenges are common to the development of new chemical entities, generic pharmaceutical manufacturing and contract research organizations. To help enhance productivity in compound purification and isolation Shimadzu has developed ASAPrep (Automated Scale-up from Analytical to Preparative), a unique solution to automate and optimize the purification process.

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LC/MS/MS MRM Library For Phospholipid Profiling

Shimadzu Corp.

This MRM library includes two methods: one for phospholipid classification by comprehensive analysis of the main phospholipids in biological samples, and one for fatty acid composition determination created using analytical results obtained with the classification method. The library targets phospholipids containing C14 to C22 fatty acids, and includes MRM transitions for up to 867 components. This library enables performing phospholipid profiling by conducting an initial analysis with a phospholipid classification method. This is followed by creating a method for fatty acid composition determination based on the phospholipid peak detected in the first analysis, and subsequently using this method to perform a second analysis to determine fatty acid composition.

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LC/MS/MS MRM Library For Metabolic Enzymes In Yeast

Shimadzu Corp.

An enormous number of MRM conditions need to be evaluated in order to analyze a large number of proteins. This MRM library includes such analysis conditions, greatly facilitating the initial preparation for analysis. By allowing the use of proven methods, it greatly reduces the time needed for method development.

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LC/MS/MS Method Package For Cell Culture Profiling Ver. 2

Shimadzu Corp.

This Method Package enables the analysis of 125 compounds in under 20 minutes per sample. Performing analysis separately for each compound group such as amino acids and vitamins makes profiling of cell culture components very laborious, but with this method package a large number of culture medium components and secreted metabolites can be analyzed simultaneously.Compared to the previous version, several metabolites derived from amino acids, nucleic acids and the TCA cycle have been added, allowing even more comprehensive profiling information to be gathered.

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LC/MS/MS Method Package For Primary Metabolites

Shimadzu Corp.

Shimadzu Method Packages deliver conditions for efficient and simultaneous multi-component analysis. They enable the user to quickly and easily implement complex methods without costly and laborious method development by providing sample preparation protocols, LC separation conditions, and MS acquisition parameters.

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LC/MS/MS Method Package For Lipid Mediators

Shimadzu Corp.

Lipid mediators (bioactive lipids) have important physiological functions and have been associated with allergies, thrombosis and lifestyle-related diseases. This method package provides a simultaneous analysis method that encompasses totally 214 compounds, which include 196 compounds of lipid mediators derived from arachidonic acid cascade and 18 internal standard compounds.

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Multi-omics Analysis Package

Shimadzu Corp.

The Multi-omics Analysis Package, developed for metabolic engineering applications, provides the ability to automatically generate metabolic maps and perform a variety of data analysis for the vast data generated in fields like metabolomics, proteomics and flux analysis. It offers a powerful platform to support drug discovery, bioengineering and other life science research applications.

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