Isothermal Microcalorimetry

Isothermal Microcalorimetry is an extremely sensitive technique complementary to TA Instruments differential scanning calorimeters. TAM is a microcalorimeter system represented by TAM IV, TAM IV-48 and TAM Air.

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Microcalorimeters

TA Instruments

TA Instruments’ Isothermal Titration Calorimetry (ITC), Differential Scanning Calorimetry (DSC), and Isothermal Calorimetry systems are powerful analytical techniques for in-depth characterization of molecular binding events and structural stability. Thermodynamic binding signatures not only reveal the strength of a binding event, but the specific or nonspecific driving forces involved. Structural stability profiles from DSC reveal strengths and weaknesses in higher order structure and define the behavior of individual domains and their interactions. The TA Instruments Affinity ITC, Nano ITC and Nano DSC provide the performance, reliability and ease-of-use required for the most demanding applications in drug discovery, protein-protein interactions, structure-function characterization and more.

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Isothermal Titration Calorimetry

TA Instruments

ITC instruments are designed for the most challenging life science laboratory environments that require high sensitivity, high productivity and the most advanced ITC technology.

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Differential Scanning Calorimetry

Nano DSC - TA Instruments

The Nano DSC differential scanning calorimeter is designed to characterize the molecular stability of dilute in-solution biomolecules. The Nano DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell. Automated, unattended continuous operation with increased sample throughput is achieved with the optional Nano DSC Autosampler.

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Isothermal Microcalorimetry

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Microcalorimeters

Isothermal Titration Calorimetry

Differential Scanning Calorimetry