Analytical Research Services

Teledyne Hanson Research (Hanson Research Corp.)

Teledyne Hanson’s Analytical Research Center (ARC) provides analytical lab services in support of pharmaceutical, nutraceutical, and cosmeceutical research and development, manufacturing, quality control, and regulatory compliance. The ARC, located in Chestnut Ridge, New York, leverages Hanson’s decades of experience and innovation in the fields of dissolution, diffusion, and disintegration testing. Hanson Research, founded in 1951, is the innovator of the Model A cell shown in USP <1724> and the joint developer, along with the U.S. FDA and USP, of modern-day six-vessel dissolution testing instruments.

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Dissolution Testing

Teledyne Hanson Research

Dissolution testing determines the release rate of an active pharmaceutical ingredient in tablet or capsule form as it dissolves into solution. Dissolution replicates the process of oral dosage formulations as they dissolve and are assimilated into the GI tract.

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Six-Position Dissolution Test Station

VISION® G2 CLASSIC 6™ - Teledyne Hanson Research

The Vision G2 Classic 6 dissolution tester is the compact, rugged workhorse sibling to the Vision G2 Elite 8. Named in honor of the world’s first dissolution tester, a six-position test station introduced by Hanson Research in 1969, the G2 Classic 6 is precision engineered to ease the rigors of manual dissolution testing. The G2 Classic 6 meets and exceeds worldwide standards including compliance with USP, FDA, ASTM, EP, JP, CE, CSA, RoHS, and 21 CFR Part 11.

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8-Sample Manual Dissolution Tester

VISION® G2 ELITE 8™ - Teledyne Hanson Research

The Vision G2 Elite 8 dissolution tester is a versatile performance machine, built with the highest quality components and engineering. The G2 Elite 8’s ergonomic design and workhorse performance make it ideal for automation and extended applications as well as for 8-sample manual testing. The G2 Elite 8 meets and exceeds worldwide standards including compliance with USP, US FDA, ASTM, EP, JP, CE, CSA, RoHS, and 21 CFR Part 11.

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14-Vessel Comparative Dissolution Tester

CD14 - Teledyne Hanson Research

The Teledyne Hanson 14-vessel CD14 Comparative Dissolution Tester runs two methods simultaneously or independently—ideal for bioequivalence studies of generic vs. innovator drug formulations. The 14 stirring positions allow for 6+1 or 12+2 configurations for improved workload efficiency in R&D, formulations, QC, and stability-test labs. With digital temperature probes at 12 positions the CD14 comparative dissolution tester is able to test two different formulations with separate settings for every parameter under the same temperature conditions.

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Autosampler with 6 or 8 Sampling Channels, DissoScan (1-bath) or Maximizer (up to 3 baths) Configurations

VISION® AUTOPLUS™ - Teledyne Hanson Research

The Vision AutoPlus autosampler is a modern upgrade of the popular Hanson legacy AutoPlus autosampler. The Vision AutoPlus comes with a choice of 6 or 8 sampling channels, and DissoScan™ (1-bath) or Maximizer™ (up to 3 baths) configurations. Precision syringe pump mechanics, all-inert tubing and valves, and color touchscreen programming with up to 100 protocols are standard on each instrument.

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Percision Autosampling with All-Inert Syringes, Valves, Tubing, and Fluidics

CD AUTOPLUS™ & AUTOFILL™ - Teledyne Hanson Research

The CD AutoPlus™ is a precision autosampling system with all-inert syringes, valves, tubing, and fluidics, designed for plug-and-playintegration with CD14 Comparative Dissolution Testers. With 6 syringes (10 mL capacity) and a volume accuracy of ± 1% (0.1 mL), the CD AutoPlus easily accommodates sampling intervals under 5 minutes.

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Software for Vision® and CD Testers

Protocol Manager™ - Teledyne Hanson Research

Protocol Manager™ software provides fast, easy, drag-and-drop protocol management for Vision® and CD testers. Pharmaceutical research, manufacturing, and QC labs running Teledyne Hanson’s Vision and/or CD14 dissolution testers can now manage users, methods, and instruments more efficiently than ever before. Our Protocol Manager software eliminates all instrument-based connectivity and storage limits by connecting your Hanson systems to a centralized protocol database on a Windows® client/server operating system. The spacious, easy-to-use, desktop interface provides drag-and-drop simplicity and increased support for 21 CFR Part 11 compliance.

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Automatic Media Preparation

Media-Mate Plus™ - Teledyne Hanson Research

In addition to requiring precise control of dissolution media temperatures, the United States Pharmacopeia (USP) and Food and Drug Administration (FDA) Guidance for Industry state that, if dissolved gases in dissolution medium affect the dissolution results of products then the medium must be degassed. Media preparation is typically a time-consuming and labor-intensive task in the dissolution laboratory. Heating and dissolution media preparation required temperature, deaeration (removal of dissolved gases), and precise volumetric dispensing into flasks requires diligence, patience and care. Automated methods can streamline these tasks while freeing the chemist for more productive analytical work. Automation carries the added benefit of providing instrument validation while eliminating human error. The Hanson Media-Mate Plus system was designed and engineered specifically to meet these requirements. A large pre-heat tank controls media temperature, while its exclusive deaeration-dispense assembly removes dissolved gases and accurately dispenses precise adjusted media volumes into groups of 6 or 7 dissolution flasks simultaneously – all in less than five minutes. The Media-Mate Plus uses a self-tuning PID controller and a Teflon heater to heat the media. Media is moved by low pressure or vacuum and directed by a two-position, multi-channel pinch valve. The media is deaerated by a thin film vacuum process. The media volume is accurately measured by a user-set incremental measuring system. The system may be easily moved throughout the laboratory, servicing several dissolution baths. The Media-Mate Plus is the perfect media-prep system for a busy dissolution lab that demands both speed and accuracy. Built on a unique ergonomic cart, the Media-Mate Plus offers maximum portability for easy servicing of many dissolution test stations.

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